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PERITONEAL CANCER: PRIMäR, SEKUNDäR, SYMTOM

Background Ovarian cancer is the 7th cause of cancer mortality and the 7th most common cancer in women throughout the world ().A study on Iranian women indicated the increasing trends and the incidence of ovarian cancer mortality from 1999 to 2004 ().The general mortality rate of ovarian cancer dramatically increased during these years from 0 HE4. In benign gynecological conditions, HE4 is less frequently elevated than CA125 . 7-10. In a study of 1042 women with pelvic mass . 10 • HE4 was elevated in only 3% of premenopausal women. with endometriosis, while CA125 was elevated in 72%. HE4 can aid in conservative management.

Since HE4 is sensitive to hormonal treatment and robust towards menstrual cycle variation, HE4 is potentially superior to CA125 as an endometriosis marker and therefore has greater The level of HE4 is overexpressed in ovarian tumors. Its specificity is 94% and its level is not affected by endometriosis cysts. The combined measures of CA125 and HE4 have proved to be highly efficient with an area under the curve (AUC) of up to 0.96. examinations.

showed that serum HE4 and CA125 concentrations were significantly higher in patients with ovarian cancer compared with levels observed in patients with benign disease or healthy controls.

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Abstract: OBJECTIVE:This study aims to investigate the clinical significance of serum Smac, HE4 and CA125 alone or combined for detecting endometriosis-associated ovarian cancer (EAOC). METHODS:The level of serum Smac, HE4 and CA125 in 40 healthy controls, 40 cases of benign endometriosis ovarian tumor, and 60 cases of EAOC were detected by ELISA and electrochemical immune method. RESULTS: Serum CA-125 and HE4 levels were significantly higher in patients with endometrial cancer, compared to the controls (p=2.67×10-4, 1.36×10-7, respectively).

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observed a marked difference between HE4 levels, which was increased only in 3% of cases, compared to CA125, which was elevated in 67% of cases . Hamed et al. showed that serum HE4 and CA125 concentrations were significantly higher in patients with ovarian cancer compared with levels observed in patients with benign disease or healthy controls. Since HE4 is sensitive to hormonal treatment and robust towards menstrual cycle variation, HE4 is potentially superior to Ca125 as an endometriosis marker and therefore has greater potential as a OBJECTIVE: This study aims to investigate the clinical significance of serum Smac, HE4 and CA125 alone or combined for detecting endometriosis-associated ovarian cancer (EAOC).

Based on the results obtained in the study, the cut-off value for HE4 was established at 186 pmol/l and 2013-01-23 · METHODS: CA125 and HE4 serum levels were determined in 30 patients with epithelial ovarian cancer (21 serous, 6 endometrioid and 3 mucinous tumors), 20 patients with benign gynecological diseases (8 patients with ovarian cyst, 5 patients with endometriosis, 4 patients with fibroid and 3 patients with pelvic inflammatory disease) and 20 healthy women. Abstract: OBJECTIVE:This study aims to investigate the clinical significance of serum Smac, HE4 and CA125 alone or combined for detecting endometriosis-associated ovarian cancer (EAOC). METHODS:The level of serum Smac, HE4 and CA125 in 40 healthy controls, 40 cases of benign endometriosis ovarian tumor, and 60 cases of EAOC were detected by ELISA and electrochemical immune method. RESULTS: Serum CA-125 and HE4 levels were significantly higher in patients with endometrial cancer, compared to the controls (p=2.67×10-4, 1.36×10-7, respectively). A diagnostic model that combines serum CA-125 and HE4 levels and body mass index separated patients with endometrial cancer from controls, with AUC of 0.804, sensitivity of 66.7%, and specificity of 84.6%. 2013-07-01 · The use of HE4, CA125 and CA72-4 biomarkers for differential diagnosis between ovarian endometrioma and epithelial ovarian cancer Abstract. Endometriosis is frequently associated with high levels of CA125.
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Since HE4 is sensitive to hormonal treatment and robust towards menstrual cycle variation, HE4 is potentially superior to Ca125 as an endometriosis marker and therefore has greater potential as a OBJECTIVE: This study aims to investigate the clinical significance of serum Smac, HE4 and CA125 alone or combined for detecting endometriosis-associated ovarian cancer (EAOC). 2012-08-21 · As HE4 plasma levels are not elevated in patients with endometriosis HE4 can be very useful as an additional marker to CA 125 in premenopausal women when there is suspicion of endometriosis. In premenopausal women we found HE4 increased mainly the specificity at the same sensitivity as CA125 in patients with malignancy. 2021-02-01 · HE4 and CA125 displayed wide ranges across the cohort; 22.7 to 1880 pmol/L (median 81) for HE4 and 3.3-1360 U/mL (median 9.3) for CA125.
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Since HE4 is sensitive to hormonal treatment and robust towards menstrual cycle variation, HE4 is potentially superior to CA125 as an endometriosis marker and therefore has greater potential as a marker for the identification of women at risk of developing ovarian cancer. Conclusion: Detection of levels of serum CA125 and HE4 can help diagnose endometriotic cysts.

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CA125 is elevated in ovarian cancer and endometriosis, but not in endometrial cancer. 5. 2018-12-22 CA125 combined with HE4 detection can improve the sensitivity, specificity and accuracy of diagnosis of endometriotic cysts. Serum TK1 has no significant clinical significance in the diagnosis of patients with endometriosis. following biomarkers: CA125, HE4 and CA72-4. Results: Serum CA125 concentration was elevated in both patients with ovarian endometriosis and ovarian cancer but not in patients with other benign ovarian masses.